Neurexin



Neurexins (NRXN) are a family of presynaptic proteins which bind to the postsynaptic Neuroligin (NLGN) to form a complex which attaches neurons. The NRXN family contains 4 members which are numbered 1 to 4. The NRXN-α contains 6 homologous LNS domains while the NRXN-β contains only LNS6.

For Structural Analysis of Neurexin, See: Neuroligin-Neurexin Interaction

3D Structures of Neurexin
Update June 2011

NRXN
3mw2 – mNRXN-1α LNS domain+splice insert 4 – mouse

3bod, 3bop - mNRXN-1α LNS domain

3mw3, 2r1b - rNRXN-1α LNS domain+splice insert 4 – rat

2r16 - rNRXN-1α LNS domain+Ca

1c4r - rNRXN-1α LNS domain

3mw4 - mNRXN-1α LNS domain

2h0b - bNRXN-1α LNS2 domain – bovine

3asi - bNRXN-1α LNS25-EGF3-LNS6 domains

NRXN+NLGN
2xb6, 2wqz – rNRXN-1α LNS domain +hNLGN-4 cholinesterase domain

3b3q - hNRXN-1α LNS domain+mNLGN-4 cholinesterase domain

3biw - rNRXN-1α LNS domain+rNLGN-1 cholinesterase domain